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- Meet a child genius named Sheldon Cooper (already seen as an adult in The Big Bang Theory (2007)) and his family. Some unique challenges face Sheldon, who is socially impaired.
- A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- He's smart. He's lovable. He's Dexter Morgan, America's favorite serial killer, who spends his days solving crimes and nights committing them.
- A chemistry teacher diagnosed with inoperable lung cancer turns to manufacturing and selling methamphetamine with a former student in order to secure his family's future.
- Explores the high-pressure experiences of the first responders who are thrust into the most frightening, shocking, and heart-stopping situations.
- Shaun Murphy, a young surgeon with autism and Savant syndrome, is recruited into the surgical unit of a prestigious hospital.
- Two brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons, and gods that roam the earth.
- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- New Jersey mob boss Tony Soprano deals with personal and professional issues in his home and business life that affect his mental state, leading him to seek professional psychiatric counseling.
- Follows the Major Case Response Team (MCRT) from the Naval Criminal Investigative Service (NCIS), as they get to the bottom of criminal cases connected to Navy and Marine Corps personnel.
- A scrappy, feisty, fiercely loyal Chicago family makes no apologies.
- Claire Beauchamp Randall, a nurse in World War II, mysteriously goes back in time to Scotland in 1743. There, she meets a dashing Highland warrior and gets drawn into an epic rebellion.
- The series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- Follows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- Various chronicles of deception, intrigue, and murder in and around frozen Minnesota. All of these tales mysteriously lead back one way or another to Fargo, North Dakota.
- Three different, but related, families face trials and tribulations in their own uniquely comedic ways.
- Comedy series following the exploits of Det. Jake Peralta and his diverse, lovable colleagues as they police the NYPD's 99th Precinct.
- The continuing misadventures of neurotic New York City stand-up comedian Jerry Seinfeld and his equally neurotic New York City friends.
- This spinoff of the critically acclaimed show Grey's Anatomy follows the lives of the men and women of firehouse station 19 in Seattle, Washington.
- The quirky spin on Conan Doyle's iconic sleuth pitches him as a "high-functioning sociopath" in modern-day London. Assisting him in his investigations: Afghanistan War vet John Watson, who's introduced to Holmes by a mutual acquaintance.
- Two F.B.I. Agents, Fox Mulder the believer and Dana Scully the skeptic, investigate the strange and unexplained, while hidden forces work to impede their efforts.
- A new FBI profiler, Elizabeth Keen, has her entire life uprooted when a mysterious criminal, Raymond Reddington, who has eluded capture for decades, turns himself in and insists on speaking only to her.
- A hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- Set almost 100 years after Captain Kirk's 5-year mission, a new generation of Starfleet officers sets off in the U.S.S. Enterprise-D on its own mission to go where no one has gone before.
- Professional writer and amateur sleuth Jessica Fletcher uses her intellect, charm, and persistence to get to the bottom of every crime she encounters.