- The character of Paris Geller on Gilmore Girls (2000) was written for her because she was wanted in the show.
- Initially auditioned for the role of Rory Gilmore in Gilmore Girls (2000).
- Mother, with ex-husband Paul Adelstein, of daughter Josephine Elizabeth Weil-Adelstein (b. April 20, 2010).
- Is a natural brunette, but after she got the role of Paris Geller in Gilmore Girls (2000), she was required to dye her hair blonde to better serve as the foil to Rory Gilmore.
- Weil had aspirations of becoming an archaeologist in her younger years, because of the Indiana Jones film trilogy and a childhood crush on Harrison Ford.
- Although born in New Jersey, U.S.A., she was considered transient during her childhood as her parents traveled around Europe.
- Was in a relationship with Charlie Weber from 2016 to 2019.
- She is of Ashkenazi Jewish (father) and Finnish, Norwegian, English, and Scots-Irish/Northern Irish (mother) ancestry. She was raised in Reform Judaism.
- In both How to Get Away with Murder (2014) and Gilmore Girls (2000), Liza's character has a romantic relationship with a man named Asher.
- She and her Gilmore Girls (2000) co-star, Dakin Matthews (Hanlin Charleston, headmaster of Chilton), both appeared in the same episode of the first season of the The West Wing (1999), Take Out the Trash Day (2000).
- Engaged to Paul Adelstein (May 2006)
- Aunt of Eloise Estevez, Scarlett Estevez, and Ben Estevez, through her sister, Samantha Weil.
- She became an aunt in 2006, when her sister, Samantha Weil, had a daughter after she moved to the Los Angeles area.
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