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- DirectorDavid CronenbergStarsPeter WellerJudy DavisIan HolmAfter developing an addiction to the substance he uses to kill bugs, an exterminator accidentally kills his wife and becomes involved in a secret government plot being orchestrated by giant bugs in a port town in North Africa.
- DirectorRichard LinklaterStarsKeanu ReevesWinona RyderRobert Downey Jr.An undercover cop in a not-too-distant future becomes involved with a dangerous new drug and begins to lose his own identity as a result.
- DirectorTerry GilliamStarsJohnny DeppBenicio Del ToroTobey MaguireAn oddball journalist and his psychopathic lawyer travel to Las Vegas for a series of psychedelic escapades.
- DirectorWerner HerzogStarsNicolas CageEva MendesRussell M. HaeuserTerence McDonagh is a drug- and gambling-addled detective in post-Katrina New Orleans investigating the killing of five Senegalese immigrants.
- DirectorGreg HarrisonStarsChris FerreiraMackenzie FirgensElizabeth SunAn inside look into one night in the San Francisco underground rave scene.
- DirectorPaul Thomas AndersonStarsMark WahlbergJulianne MooreBurt ReynoldsBack when sex was safe, pleasure was a business and business was booming, an idealistic porn producer aspires to elevate his craft to an art when he discovers a hot young talent.
- DirectorLou AdlerTommy ChongStarsCheech MarinTommy ChongStrother MartinTwo stoners unknowingly smuggle a van - made entirely of marijuana - from Mexico to L.A., with incompetent Sgt. Stedenko on their trail.
- DirectorDarren AronofskyStarsEllen BurstynJared LetoJennifer ConnellyThe drug-induced utopias of four Coney Island people are shattered when their addictions run deep..
- DirectorDanny BoyleStarsEwan McGregorEwen BremnerJonny Lee MillerRenton, deeply immersed in the Edinburgh drug scene, tries to clean up and get out despite the allure of drugs and the influence of friends.
- DirectorJonas ÅkerlundStarsJason SchwartzmanJohn LeguizamoPatrick FugitA drug dealer introduces one of his customers, a 'speed freak', to the man who runs the meth lab. A crazy three-day adventure ensues.
- DirectorAbel FerraraStarsHarvey KeitelBrian McElroyFrank AcciaritoWhile investigating a young nun's rape, a corrupt New York City police detective, with a serious drug and gambling addiction, tries to change his ways and find forgiveness and redemption.
- DirectorD.J. CarusoStarsVal KilmerVincent D'OnofrioAdam GoldbergAfter a tragic incident, a man drifts into a world populated by thugs and speed junkies.
- DirectorQuentin TarantinoStarsJohn TravoltaUma ThurmanSamuel L. JacksonThe lives of two mob hitmen, a boxer, a gangster and his wife, and a pair of diner bandits intertwine in four tales of violence and redemption.
- DirectorPaul Thomas AndersonStarsTom CruiseJason RobardsJulianne MooreAn epic mosaic of interrelated characters in search of love, forgiveness and meaning in the San Fernando Valley.
- DirectorJoel CoenEthan CoenStarsJeff BridgesJohn GoodmanJulianne MooreJeff "The Dude" Lebowski, mistaken for a millionaire of the same name, seeks restitution for his ruined rug and enlists his bowling buddies to help get it.
- DirectorGus Van SantStarsMatt DillonKelly LynchJames Le GrosA pharmacy-robbing dope fiend and his crew pop pills and evade the law.
- DirectorKen RussellStarsWilliam HurtBlair BrownBob BalabanA psycho-physiologist experiments with drugs and a sensory-deprivation tank and has visions he believes are genetic memories.
- DirectorTommy ChongStarsCheech MarinTommy ChongEvelyn GuerreroCheech and Chong live in a decrepit old house and drive their neighbour crazy with their loud music, weed smoking and general anarchy and slacker view on life. Then Chong meets Cheech's Texan cousin Red and things kick up a notch.
- DirectorSam MendesStarsKevin SpaceyAnnette BeningThora BirchA sexually frustrated suburban father has a mid-life crisis after becoming infatuated with his daughter's best friend.
- DirectorJerry SchatzbergStarsAl PacinoKitty WinnAlan VintFollows the lives of heroin addicts who frequent "Needle Park" in New York City.
- DirectorTamra DavisStarsDave ChappelleGuillermo DiazJim BreuerThe story of three not so bright men who come up with a series of crazy schemes to get a friend out of jail.
- DirectorTed DemmeStarsJohnny DeppPenélope CruzFranka PotenteThe story of how George Jung, along with the Medellín Cartel headed by Pablo Escobar, established the American cocaine market in the 1970s in the United States.
- DirectorScott KalvertStarsLeonardo DiCaprioLorraine BraccoMarilyn SokolA teenager finds his dreams of becoming a basketball star threatened after he free falls into the harrowing world of drug addiction.
- DirectorLisa CholodenkoStarsRadha MitchellAlly SheedyPatricia ClarksonA young female intern at a small magazine company and a drug-addicted lesbian photographer slowly fall in love while exploiting each other to advance their respective careers.
- DirectorTaylor HackfordStarsJamie FoxxRegina KingKerry WashingtonThe story of the life and career of the legendary rhythm and blues musician Ray Charles, from his humble beginnings in the South, where he went blind at age seven, to his meteoric rise to stardom during the 1950s and 1960s.