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- DirectorDarren AronofskyStarsEllen BurstynJared LetoJennifer ConnellyThe drug-induced utopias of four Coney Island people are shattered when their addictions run deep..
- DirectorDanny BoyleStarsEwan McGregorEwen BremnerJonny Lee MillerRenton, deeply immersed in the Edinburgh drug scene, tries to clean up and get out despite the allure of drugs and the influence of friends.
- DirectorSteven SoderberghStarsMichael DouglasBenicio Del ToroCatherine Zeta-JonesA conservative judge is appointed by the President to spearhead America's escalating war against drugs, only to discover that his teenage daughter is a crack addict. Two DEA agents protect an informant. A jailed drug baron's wife attempts to carry on the family business.
- DirectorTaylor HackfordStarsJamie FoxxRegina KingKerry WashingtonThe story of the life and career of the legendary rhythm and blues musician Ray Charles, from his humble beginnings in the South, where he went blind at age seven, to his meteoric rise to stardom during the 1950s and 1960s.
- DirectorLee TamahoriStarsRena OwenTemuera MorrisonMamaengaroa Kerr-BellA family descended from Maori warriors is bedeviled by a violent father and the societal problems of being treated as outcasts.
- DirectorMilos FormanStarsWoody HarrelsonCourtney LoveEdward NortonThe story of controversial pornography publisher Larry Flynt, and how he became a defender of free speech.
- DirectorGus Van SantStarsMatt DillonKelly LynchJames Le GrosA pharmacy-robbing dope fiend and his crew pop pills and evade the law.
- DirectorUli EdelStarsNatja BrunckhorstEberhard AurigaPeggy BussieckA teen girl in 1970s Berlin becomes addicted to heroin. Everything in her life slowly begins to distort and disappear as she befriends a small crew of junkies and falls in love with a drug-abusing male prostitute.
- DirectorBob FosseStarsDustin HoffmanValerie PerrineJan MinerThe story of acerbic 1960s comic Lenny Bruce, whose groundbreaking, no-holds-barred style and social commentary was often deemed by the Establishment as too obscene for the public.
- DirectorJoe CarnahanStarsRay LiottaJason PatricChi McBrideWhen the trail goes cold on a murder investigation of a policeman, an undercover narcotics officer is lured back to the force to help solve the case.
- DirectorOtto PremingerStarsFrank SinatraKim NovakEleanor ParkerA junkie must face his true self to kick his drug addiction.
- DirectorSidney LumetStarsKatharine HepburnRalph RichardsonJason RobardsAt the end of a long and hot summer day, members of one family gather in a large house. Everyone has something painful and offensive to say, and their silence is even worse.
- DirectorBrian De PalmaStarsAl PacinoMichelle PfeifferSteven BauerIn 1980 Miami, a determined Cuban immigrant takes over a drug cartel and succumbs to greed.
- DirectorGary OldmanStarsRay WinstoneKathy BurkeCharlie Creed-MilesA rough, short-tempered patriarch of a working-class family sees his life and the relationships around him slowly unravel.
- DirectorPaul Thomas AndersonStarsTom CruiseJason RobardsJulianne MooreAn epic mosaic of interrelated characters in search of love, forgiveness and meaning in the San Fernando Valley.
- DirectorRobert AltmanStarsWarren BeattyJulie ChristieRene AuberjonoisA gambler and a prostitute become business partners in a remote Old West mining town, and their enterprise thrives until a large corporation arrives on the scene.
- DirectorTerry GilliamStarsJohnny DeppBenicio Del ToroTobey MaguireAn oddball journalist and his psychopathic lawyer travel to Las Vegas for a series of psychedelic escapades.
- DirectorAnurag KashyapStarsAbhay DeolMahie GillKalki KoechlinAfter breaking up with his childhood sweetheart, a young man finds solace in drugs. Meanwhile, a teenage girl is caught in the world of prostitution. Will they be destroyed, or will they find redemption?
- DirectorNicholas RayStarsJames MasonBarbara RushWalter MatthauA seriously-ill schoolteacher becomes dependent on a "miracle" drug that begins to affect his sanity.
- DirectorSidney LumetStarsTreat WilliamsJerry OrbachRichard ForonjyA New York City narcotics detective reluctantly agrees to cooperate with a special commission investigating police corruption, and soon realises he's in over his head, and nobody can be trusted.
- DirectorAlan ParkerStarsBob GeldofChristine HargreavesJames LaurensonA confined but troubled rock star descends into madness in the midst of his physical and social isolation from everyone.
- DirectorDarren AronofskyStarsSean GulletteMark MargolisBen ShenkmanA paranoid mathematician searches for a key number that will unlock the universal patterns found in nature.
- DirectorRyan FleckStarsRyan GoslingAnthony MackieShareeka EppsAn inner-city junior high school teacher with a drug habit forms an unlikely friendship with one of his students after she discovers his secret.
- DirectorThomas VinterbergStarsGustav Fischer KjærulffSebastian BullMads Broe AndersenTwo brothers meet at their mother's funeral, each in his way on a path of self-destruction, both haunted by a tragedy in their youth.
- DirectorBilly WilderStarsRay MillandJane WymanPhillip TerryThe desperate life of a chronic alcoholic is followed through a four-day drinking bout.