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- CreatorDavid E. KelleyStarsLoretta DevineAnthony HealdFyvush FinkelThe lives of 10 faculty members at a high school in Boston weave in and out of dealing with trouble-makers, having a personal life, and keeping sanity.
- CreatorVictor FrescoStarsJay HarringtonPortia de RossiAndrea AndersIn an amoral science-based company, a manager tries to keep control of his scientists while being pressured by his shrewd boss.
- CreatorDenis LearyPeter TolanStarsDenis LearyMichael LombardiSteven PasqualeTommy Gavin deals with the fears of his job as a firefighter and seeing his ex-wife dating other men.
- CreatorMark SchwahnStarsChad Michael MurrayJames LaffertyHilarie Burton MorganHalf-brothers Lucas and Nathan Scott trade between kinship and rivalry both on the basketball court and in the hearts of their friends in the small, but not so quiet town of Tree Hill, North Carolina.
- CreatorJosh SchwartzStarsMischa BartonAdam BrodyPeter GallagherA troubled youth becomes embroiled in the lives of a close-knit group of people in the wealthy, upper-class neighborhood of Newport Beach, Orange County, California.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorRob ThomasStarsKristen BellJason DohringEnrico ColantoniAfter her best friend is murdered, and her father is removed as county Sheriff, Veronica Mars dedicates her life to cracking the toughest mysteries in the affluent town of Neptune.
- CreatorShana Goldberg-MeehanScott SilveriStarsMatt LeBlancPaulo CostanzoDrea de MatteoIn this spin-off of Friends (1994), Joey Tribbiani moves to Los Angeles to pursue his acting career.
- StarsJason AlexanderWendy MakkenaDaniella MonetTony Kleinman and his partner, former professional athlete Bernie Widman, co-host a television talk show in Philadelphia devoted primarily to sports and athletes of all disciplines.
- CreatorLinwood BoomerMichael GloubermanGary MurphyStarsFrankie MunizBryan CranstonJustin BerfieldA gifted young teen tries to survive life with his dimwitted, dysfunctional family.
- CreatorAllison M. GibsonStarsReba McEntireJoAnna Garcia SwisherSteve HoweyReba McEntire stars as the titular character in this smash sitcom about a single mom of three, navigating life in a Houston suburb.
- CreatorNat BernsteinMitchel KatlinStarsJohn GoodmanJean SmartSpencer BreslinPut-upon husband and father John Barnett is always solving problems for his squabbling parents, neurotic sister and no-account brother, leaving little time for his oh-so-patient wife and their son, who's taken to wearing a blazer with the family crest on it to school. Can John keep his sanity?
- CreatorTracy NewmanJonathan StarkStarsJim BelushiCourtney Thorne-SmithLarry Joe CampbellA television show centered around a macho everyman, his loving wife, and their three precocious children.
- CreatorDon ReoDamon WayansStarsDamon WayansTisha CampbellGeorge Gore IIMichael Kyle longs for a traditional life, but his day-trader wife Janet, gangsta rap-worshipping son Michael Jr., and brooding daughters Claire and Kady make his dream just that ... a dream.
- CreatorMark BrazillTerry TurnerBonnie TurnerStarsGlenn HowertonTinsley GrimesChyler LeighThat '80s Show is a half-hour ensemble comedy focusing on a group of twenty-somethings finding their way through the '80s in San Diego.
- CreatorBryan FullerStarsLee PaceAnna FrielChi McBrideA pastry chef with the power to bring dead people back to life solves murder mysteries with his resurrected childhood sweetheart, a cynical private investigator, and a lovesick waitress.
- CreatorAnthony E. ZuikerStarsWilliam PetersenLaurence FishburneTed DansonIn Las Vegas, a squad of forensic investigators are trained to solve crimes by meticulously examining the evidence. They employ advanced technology and their rationality to detect the perpetrators.
- CreatorBrandon CampMike ThompsonStarsDominic PurcellJayne BrookJohn Marshall JonesA man who seems to know everything but his own name helps police solve crimes as he searches for his identity.
- CreatorEric KripkeStarsJared PadaleckiJensen AcklesJim BeaverTwo brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons, and gods that roam the earth.
- CreatorEileen HeislerDeAnn HelineStarsBrooke ShieldsKim RaverLindsay PriceA look at the lives of Nico, Wendy, and Victory -- three of "New York's 50 Most Powerful Women," according to The New York Post.
- CreatorMatt NixStarsJeffrey DonovanGabrielle AnwarBruce CampbellA spy recently disavowed by the U.S. government uses his special ops training to help others in trouble.
- CreatorAndy BreckmanStarsTony ShalhoubJason Gray-StanfordTed LevineThe series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- CreatorSteve FranksStarsJames Roday RodriguezDulé HillTimothy OmundsonWhen a novice sleuth convinces the police he has psychic powers, he and his reluctant best friend are hired on as consultants to help solve complicated cases.
- CreatorGreg BerlantiStarsTreat WilliamsGregory SmithEmily VanCampA widowed brain surgeon from Manhattan moves his two children to the small mountain town of Everwood, Colorado.
- CreatorVictor FrescoStarsZachary KnightonCharlie FinnRachelle LefevreTwo teenage slackers try to make a living at a fast-food place at a local shopping mall while one deals with his dysfunctional family.