- During the making of The Thing (1982), Rob lived on the set in Los Angeles, California, where he worked seven days a week for over a year. He slept on set and in laboratories. When the project was completed, John Carpenter sent him to the hospital where he was diagnosed with extreme exhaustion.
- When he was 14 years old, Rob Bottin sent Rick Baker a letter containing a picture he drew with the hope of getting his autograph in return. When Baker received the letter, he was so impressed that such a young man could create such a beautiful drawing that he offered to hire Bottin as his apprentice instead.
- His eye popping, de-pressurized effect for Total Recall (1990) was the original screenplay concept of Palmer (David Clennon's) transformation in The Thing (1982).
- Portrayed the zombie ghost of the pirate captain Blake in the end of John Carpenter's The Fog (1980), on which he also provided special make-up effects. Carpenter said it worked out great since Bottin is a fairly tall man.
- Was originally set to direct Freddy vs. Jason (2003) back in 1998.
- Was one of a number of writers who submitted a script for Freddy vs. Jason (2003).
- Last name is pronounced bo-TEEN.
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