- Son of Stacy Keach Sr., younger brother of Stacy Keach.
- Johnny Cash was the godfather of his son John and Christopher Reeve was the godfather of his son Kris.
- Along with his wife Jane Seymour, hosted the private wake for David Carradine at their home, which was attended by Steve Railsback, Sally Kirkland, James Cromwell, Vicki Roberts, Rob Schneider, Daryl Hannah, and other luminaries.
- Ex-wife, Holly Collins, is Judy Collins' sister.
- Met Jane Seymour on the set of Sunstroke (1992).
- Twin boys, John Stacy Keach and Kristopher Steven Keach (b. 1995), with Jane Seymour.
- Was up for the role of "Freddy Krueger" in the Wes Craven classic, A Nightmare on Elm Street (1984), before turning it down due to a scheduling conflict.
- Father, with Holly Collins, of son Kalen Keach.
- Born on the 6 year anniversary of the Japanese attack on Pearl Harbor.
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