- His wife is the daughter of Ian Anderson, lead singer of the rock group Jethro Tull.
- Apple Martin, the daughter of Coldplay's Chris Martin and Gwyneth Paltrow, served as a flower girl at his wedding.
- His voice is familiar in the United Kingdom as he provides voice-overs for both television and radio advertising, as well as narration for documentaries.
- His brother is a teacher and he attended school with him for a few weeks to research his role in Teachers (2001).
- Andrew is a supporter of Shelter, the British charity for the homeless.
- In 2001, Andrew went to Ghana for a month with Voluntary Services Overseas to experience how volunteers and development agencies work first hand.
- In 2004, Empire magazine nominated Andrew for the Best Newcomer Award for his performance as Mark in Richard Curtis' film Love Actually (2003).
- Andrew famously said in a 2017 interview: 'I'm choosing to ignore the whole thing. I don't watch the show at all. I am allergic to my own face.'.
- In 2014, Andrew has appeared in a video in support of the Robin Hood tax. Along with others in the video, he has encouraged the public to get behind the measure, noting its "incredible support from people across Europe".
- His father was an English civil engineer and his mother is a South African nurse.
- Has two children with Gael Anderson: a daughter Matilda Clutterbuck (b. 2007) and a son Arthur Clutterbuck (b. 2010).
- Andrew worked with London's National Youth Theatre.
- Andrew attended Beechen Cliff Secondary School in Bath, Somerset (UK), before going onto attend the Royal Academy of Dramatic Arts (RADA).
- Is close friends with co-star Norman Reedus.
- Is friends with co-star Chiwetel Ejiofor.
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