- Siegel and producer Walter Wanger had been desperately trying to persuade the warden of San Quentin Prison to allow the use of the facility to film Riot in Cell Block 11 (1954), but the warden had adamantly refused. After the final meeting in the prison, when the warden had said there was nothing Siegel or Wanger could do to persuade him to allow filming there, Siegel turned to speak to his assistant, Sam Peckinpah. When the warden heard Peckinpah's name, he asked, "Are you related to Denver Peckinpah?" Sam replied that Denver was his father. It turned out that Denver Peckinpah was a well-known jurist in northern California who had a reputation as a "hanging judge" and the warden had long been an admirer of his. He immediately granted the company permission to shoot the movie in San Quentin.
- Was mentor to Clint Eastwood. Eastwood dedicated his film Unforgiven (1992) to him.
- During filming of Dirty Harry (1971), Siegel fell ill with the flu, and Clint Eastwood stepped in temporarily as director, during a critical scene involving a suicide jumper. This was Eastwood's first unbilled credit as director.
- Was Sam Peckinpah's mentor.
- Siegel was the first director to be credited by the Director's Guild of America's universal pseudonym Alan Smithee, for Death of a Gunfighter (1969). Siegel wished to remain uncredited because he felt the film's star, Richard Widmark, ruined the picture by insisting on creative control that usurped Siegel's authority as director, and also because Widmark had fired original director Robert Totten, who completed most of the picture, and Siegel felt that if anyone should be credited for the film it should have been Totten and not him.
- Was eager to direct movies as early as 1942, but his contract with Warner Brothers kept him restricted to doing editing and montage sequences. Studio chief Jack L. Warner refused to let Siegel out of his contract because he wanted to utilize his exceptional montage skills.
- While filming Flaming Star (1960) starring Elvis Presley, he drove Presley's new Rolls-Royce for two weeks.
- Interviewed in Peter Bogdanovich's "Who the Devil Made It: Conversations With Robert Aldrich, George Cukor, Allan Dwan, Howard Hawks, Alfred Hitchcock, Chuck Jones, Fritz Lang, Joseph H. Lewis, Sidney Lumet, Leo McCarey, Otto Preminger, Don Siegel, Josef von Sternberg, Frank Tashlin, Edgar G. Ulmer, Raoul Walsh." NY: Alfred A. Knopf, 1997.
- He originally intended for Invasion of the Body Snatchers (1956) to end with the hero, Dr. Miles Bennell (Kevin McCarthy) on the highway shouting to the motorists, "You're next! You're next!" but Allied Artists wanted a happier ending that assured the audience the hero's efforts had not been in vain. Siegel subsequently added the opening with Miles in the hospital recounting his story to the other two doctors, who find out at the end of the film that the pod people are real and contact the FBI.
- He's the son of a mandolin virtuoso.
- Began in the film business in 1934. His uncle, Jack Saper, was a producer at Warner Brothers and arranged for Siegel to get an interview with production chief Hal B. Wallis, who gave him a job in the film library at that studio.
- In Telefon (1977), where Houston, Texas, is the location of a subplot in the story, the interior of the Hyatt Regency is not in the one in Houston but actually the one located at 5 Embarcadero Center in San Francisco, which is the same location for the disaster epic The Towering Inferno (1974). San Francisco was also the setting for three other Siegel films: The Lineup (1958), Dirty Harry (1971) and Escape from Alcatraz (1979).
- In Charley Varrick (1973) and Telefon (1977), a yellow Lincoln Continental sedan is used as part of a major plot in the film. In both films, the Continental sedan is involved in a front-end collision and subsequently totalled.
- Contains spoilers. Don Siegel directed, in their last film roles, Ronald Reagan (Browning) in The Killers (1964) and John Wayne (Books) in The Shootist (1976) in which both their characters were killed in their final scenes as actors.
- Siegel and screenwriter Stephen Geller (The Valachi Papers (1972), Slaughterhouse-Five (1972)) once collaborated on a script of "The First Deadly Sin" (based on the novel), to be directed by Siegel. The project fell through, however, and a different version was filmed several years later.
- He has directed two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Invasion of the Body Snatchers (1956) and Dirty Harry (1971).
- Don Siegel married his first wife in the sixteenth district of Paris.
- Don Siegel says in his autobiography that he was supposed to direct Das Boot, the war film about a German submarine. But there was a major issue between him and his usual screen writer that provoked to Siegel a brain vascular. So Don Siegel abandoned the project.
- Biography in: John Wakeman, editor. "World Film Directors, Volume One, 1890-1945." Pages 997-1001. New York: The H.W. Wilson Company, 1987.
- Don had a home in the Longridge Estates, in the San Fernando Valley section of Los Angeles.
- Father of Anney Siegel-Wamsat and actor Kristoffer Tabori.
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