- Has five children with Eddie Murphy: daughter Bria L. Murphy (b. November 18, 1989 in Sacramento), son Myles Murphy (Myles Mitchell Murphy - b. November 7, 1992), daughter Shayne Audra Murphy (b. October 10, 1994), daughter Zola Murphy (Zola Ivy Murphy - b. December 24, 1999 in Los Angeles) and daughter Bella Murphy (b. January 29, 2002).
- Her mother is British and her father is African American.
- The nondenominational, double-ring, 16 minute ceremony was performed by Calvin O. Butts III of Harlem's Abyssinian Baptist Church. When the minister asked if anyone knew why the two shouldn't be married, Murphy turned around and glared at the wedding guests, causing much laughter.
- Met Eddie Murphy in 1988 at an NAACP Image Awards show. They lived together for a year and a half before they married. They were married at the Grand Ballroom of The Plaza Hotel in New York City.
- The flower girl at her wedding to Eddie Murphy was their daughter, Bria L. Murphy. Nicole's stepsister, Wilma Worrell, was the matron of honor. Best man was Vernon Lynch, Eddie's stepfather. Murphy's brothers, Charlie Murphy (aka Charlie) and Vernon Lynch, Jr., and his cousin Ray Murphy Jr., were his groomsmen.
- In her wedding to Eddie Murphy, she walked down the aisle to the song, "Don't Give Up on Love", which Murphy had performed on his "Love's Alright" album.
- She is an Associate with Pre-Paid Legal Services, Inc.
- She, Eddie Murphy, and Bria left the ceremony to Whitney Houston's "I'm Every Woman."
- Wedding dress was made of white silk and satin, it was low-cut and off-the-shoulder and featured French Alençon lace and rosettes. The cathedral train was 12 feet long. Her cathedral tulle veil was edged in Belgian embroidery and decorated with Austrian crystals and pearls.
- Her mother, Ellen Mitchell, died on November 4, 2019.
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