- Midfielder for Deportivo Pereira (1990), Atlético Nacional (1991-1997, 2004-05), Boca Juniors (1998-2002), Club Puebla (2002-03), Chacarita Juniors (2003) and Talleres de Córdoba (2004).
- Honours with Atlético Nacional: Primera A (1991, 1994, 2005 Apertura); Interamerican Cup (1997). Honours with Boca Juniors: Argentine Primera División (1998 Apertura, 1999 Clausura, 2000 Apertura); Copa Libertadores (2000, 2001); Intercontinental Cup (2000).
- 51 appearances for Colombia National Football Team (1993-2001); scored 2 goals. Member of the USA '94 and the France '98 squads.
- Was named in the South America Team of the Year in 1998, 2000 and 2001.
- Father of Mateo Serna, Lucas Serna and Dulce María Serna.
- Played well over 250 games for Atlético Nacional.
- 2005: Retired from football at the age 37.
- Played well over 100 games at the Argentine Primera División.
- Co-own of the sports company called "Imagen y Mercadeo Deportiva S.A.S".
- In 2019, was charged with money laundering in connection with a Colombian drug trafficking in Argentina and Panama.
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