Alien (1979)
Villains: Xenomorph & Ash.
(Please note: In order to qualify as 'multiple' villains, each must be shown to have different motivations and thus work towards different end goals. One film per franchise.)
Which of these films with multiple villains is your favorite?
After voting, you may discuss the poll here.
Note: All 'Batman' films represented here as well.
Note: All 'Spider-Man' films represented here as well.
Note: All 'Superman' films represented here as well.
Note: All 'X-Men' films represented here as well.
Note: All 'Pirates of the Caribbean' films represented here as well.
Villains: Shere Khan & Kaa.
(Added May 18, 2018)