Anthony Hopkins in The Silence of the Lambs (1991)
Wrong use and mixing up of words describing killers like psychopath, sociopath etc. (For example, psychopaths rarely kill people and usually lead normal lifes)
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Kevin Spacey and David Patrick Kelly in K-PAX (2001)
Lunatics have access to deep truths overseen by ordinary people
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Brad Pitt and Morgan Freeman in Se7en (1995)
Serial killers who are obsessed with religion/mythology and give mysterious clues to be found.
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Lorraine Bracco in The Sopranos (1999)
Violation of the professional relationship between doctor and patient.
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Mads Mikkelsen in Hannibal (2013)
Serial killers are exceptionally sophisticated, or even: highly cultured people are prone to crime and sadism.
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Drew Barrymore in Scream (1996)
Today's immoral teens go on rampages because they're bored and corrupted by TV and the movies
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Vera Farmiga and Freddie Highmore in Bates Motel (2013)
A bad character (trait) is explained with absolute certainty by something specific the person suffered through in their childhood.
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Mark Hamill in Star Wars: Episode IV - A New Hope (1977)
If you grow up as an orphan, your psyche will hardly be wounded, but instead you will develop heroic features.
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Christian Bale in American Psycho (2000)
Rich people have a low inhibition threshold for killing people
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Nancy Marchand in The Sopranos (1999)
The Oedipus Complex explains everything.
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Head Full of Honey (2014)
Alzheimer's makes people very funny and more sensitive.
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"Halloween" Tony Moran as Michael Myers
If no definite explanation for a killer's behavior can be found, then he must be superhuman or straight from hell.
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Sylvester Stallone, Shaka Cumbuka, Al Silvani, and Jeff Temkin in Rocky II (1979)
Believing in yourself with set free incredible physical strength in a crucial moment; this is only true for "good" people, confidence will make "bad" people lose.
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Dr. Jekyll and Mr. Hyde (1931)
Confusion of schizophrenia and Dissociative Identity Disorder ("split personality"). (suggested by ElMaruecan82, thanks to rubyfruit76 for clarifying the correct terms)
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Pat Carroll in The Little Mermaid (1989)
Mad or mean characters are prone to exaggerated laughter (suggested by borimor)
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Kathy Bates and James Caan in Misery (1990)
Bipolar people flip on a dime. (suggested by StrandedinLaLaLand)