Sort by Popularity - Most Popular Movies and TV Shows tagged with keyword "human-guinea-pig"
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1. Old (2021)
PG-13 | 108 min | Drama, Horror, Mystery
A vacationing family discovers that the secluded beach where they're relaxing for a few hours is somehow causing them to age rapidly, reducing their entire lives into a single day.
Director: M. Night Shyamalan | Stars: Gael García Bernal, Vicky Krieps, Rufus Sewell, Alex Wolff
Votes: 160,712 | Gross: $48.28M
2. The OA (2016–2019)
TV-MA | 60 min | Drama, Fantasy, Mystery
Having gone missing seven years ago, the previously blind Prairie returns home, now in her twenties with her sight restored. While many believe she is a miracle, others worry that she could be dangerous.
Stars: Brit Marling, Jason Isaacs, Scott Wilson, Alice Krige
Votes: 115,891
3. The Terminal List (2022– )
TV-MA | 55 min | Action, Drama, Thriller
A former Navy SEAL officer investigates why his entire platoon was ambushed during a high-stakes covert mission.
Stars: Chris Pratt, Constance Wu, Taylor Kitsch, Riley Keough
Votes: 107,439
4. Batman Forever (1995)
PG-13 | 121 min | Action, Adventure
Batman must battle former district attorney Harvey Dent, who is now Two-Face and Edward Nygma, The Riddler with help from an amorous psychologist and a young circus acrobat who becomes his sidekick, Robin.
Director: Joel Schumacher | Stars: Val Kilmer, Tommy Lee Jones, Jim Carrey, Nicole Kidman
Votes: 266,622 | Gross: $184.03M
5. Dark City (1998)
R | 100 min | Fantasy, Mystery, Sci-Fi
A man struggles with memories of his past, which include a wife he cannot remember and a nightmarish world no one else ever seems to wake up from.
Director: Alex Proyas | Stars: Rufus Sewell, Kiefer Sutherland, Jennifer Connelly, William Hurt
Votes: 212,328 | Gross: $14.38M
6. Three Identical Strangers (2018)
PG-13 | 96 min | Documentary, Biography, Drama
In 1980 New York, three young men who were all adopted meet each other and find out they're triplets who were separated at birth. But their quest to find out why turns into a bizarre and sinister mystery.
Director: Tim Wardle | Stars: Robert Shafran, Michael Domnitz, Howard Schneider, Ellen Cervone
Votes: 39,774 | Gross: $12.32M
7. Push (2009)
PG-13 | 111 min | Action, Sci-Fi, Thriller
Two young Americans with special abilities must race to find a girl in Hong Kong before a shadowy government organization called Division does.
Director: Paul McGuigan | Stars: Camilla Belle, Dakota Fanning, Chris Evans, Colin Ford
Votes: 115,590 | Gross: $31.81M
8. Homecoming (2018–2020)
TV-MA | 30 min | Drama, Mystery, Thriller
An anthology series centered around the mysterious Geist Group, an unconventional wellness company and their equally unorthodox program, the Homecoming Initiative.
Stars: Stephan James, Bobby Cannavale, Hong Chau, Alex Karpovsky
Votes: 27,452
9. Death Stranding (2019 Video Game)
M | Action, Adventure, Drama
Deliveryman Sam Porter must travel across a ravaged wasteland and reconnect the city states of America formed after a mysterious apocalyptic event dubbed 'death stranding' left the world in ruins and plagued by supernatural tar creatures.
Director: Hideo Kojima | Stars: Norman Reedus, Mads Mikkelsen, Léa Seydoux, Troy Baker
Votes: 11,136
10. The X Files (1998)
PG-13 | 121 min | Drama, Mystery, Sci-Fi
Mulder and Scully must fight the government in a conspiracy and find the truth about an alien colonization of Earth.
Director: Rob Bowman | Stars: David Duchovny, Gillian Anderson, John Neville, William B. Davis
Votes: 110,191 | Gross: $83.90M
11. Man Behind the Sun (1988)
Not Rated | 105 min | Drama, History, Horror
Japanese troops round up Chinese and Russian prisoners of war and take them to unit 731, where they're horribly tortured and experimented on to test new biological weapons.
Director: Tun-Fei Mou | Stars: Gang Wang, Dai Yao Wu, Runshen Wang, Zhe Quan
Votes: 7,279
12. Honey, I Blew Up the Kid (1992)
PG | 89 min | Adventure, Comedy, Family
The Szalinski family is back, this time hilarious disaster strikes when an experiment causes their new toddler son to grow many stories tall.
Director: Randal Kleiser | Stars: Rick Moranis, Marcia Strassman, Robert Oliveri, Daniel Shalikar
Votes: 46,833 | Gross: $58.66M
13. Ilsa: She Wolf of the SS (1975)
R | 96 min | Drama, Horror, Thriller
Ilsa is an evil Nazi warden at a death camp that conducts "medical experiments." Ilsa's goal is to prove women can withstand more pain and suffering than men, and therefore should be allowed to fight on the front lines.
Director: Don Edmonds | Stars: Dyanne Thorne, Gregory Knoph, Tony Mumolo, Maria Marx
Votes: 8,210
14. Bug (2006)
R | 102 min | Drama, Horror, Thriller
An unhinged war veteran holes up with a lonely woman in a spooky Oklahoma motel room. The line between reality and delusion is blurred as they discover a bug infestation.
Director: William Friedkin | Stars: Ashley Judd, Michael Shannon, Harry Connick Jr., Lynn Collins
Votes: 37,816 | Gross: $7.01M
15. Bad Surgeon: Love Under the Knife (2023)
TV-MA | 53 min | Documentary, Crime, History
Dr. Paolo Macchiarini is world famous for his revolutionary stem cell-infused windpipe transplants. There's just one problem: His patients keep dying.
Stars: Benita Alexander-Noel, Karl-Henrik Grinnemo, Oscar Simonson, Dorne Lyles
Votes: 4,506
16. The Sleep Experiment (2022)
84 min | Horror, Mystery, Thriller
Two detectives begin an investigation into a disastrous secret military experiment where five prisoners were kept awake for thirty days in a sealed gas chamber.
Director: John Farrelly | Stars: Tom Kerrisk, Rob James Capel, Will Murphy, Sam McGovern
Votes: 1,089
17. Little Joe (2019)
Not Rated | 105 min | Drama, Horror, Mystery
Alice, a single mother, is a dedicated senior plant breeder at a corporation engaged in developing new species. Against company policy, she takes one home as a gift for her teenage son and names it after him but soon starts fearing it.
Director: Jessica Hausner | Stars: Emily Beecham, Ben Whishaw, Kerry Fox, Kit Connor
Votes: 9,345
18. The Experiment (2001)
R | 120 min | Drama, Thriller
For two weeks, 20 male participants are hired to play prisoners and guards in a prison. The "prisoners" have to follow seemingly mild rules, and the "guards" are told to retain order without using physical violence.
Director: Oliver Hirschbiegel | Stars: Moritz Bleibtreu, Christian Berkel, Oliver Stokowski, Wotan Wilke Möhring
Votes: 96,100 | Gross: $0.14M
19. Captain America (1990)
PG-13 | 97 min | Action, Adventure, Sci-Fi
Frozen in the ice for decades, Captain America is freed to battle against archcriminal The Red Skull.
Director: Albert Pyun | Stars: Matt Salinger, Ronny Cox, Ned Beatty, Darren McGavin
Votes: 15,127 | Gross: $0.01M
20. Talking Walls (1987)
R | 85 min | Comedy, Drama, Romance
A sociology student films sexual encounters in a motel for his thesis, and falls in love with a French girl in the process.
Director: Stephen Verona | Stars: Stephen Shellen, Marie Laurin, Barry Primus, Sybil Danning
Votes: 212
21. La Jetée (1962)
Not Rated | 28 min | Short, Drama, Romance
The story of a man forced to explore his memories in the wake of World War III's devastation, told through still images.
Director: Chris Marker | Stars: Étienne Becker, Jean Négroni, Hélène Chatelain, Davos Hanich
Votes: 37,067
22. The Innocents (2018)
TV-MA | 60 min | Drama, Horror, Mystery
When teenagers, Harry and June, run away from their repressive families to be together, they're derailed by an extraordinary discovery--June's ability to shape-shift. A scientist tries to capture her and discover the key to her power.
Stars: Sorcha Groundsell, Percelle Ascott, Sam Hazeldine, Nadine Marshall
Votes: 6,281
23. Flesh for Frankenstein (1973)
R | 95 min | Horror, Sci-Fi
Baron Frankenstein creates two "zombies" - one male, one female - planning to mate them in order to create a master race.
Directors: Paul Morrissey, Antonio Margheriti | Stars: Joe Dallesandro, Udo Kier, Dalila Di Lazzaro, Monique van Vooren
Votes: 6,923 | Gross: $10.25M
24. Cube Zero (2004)
R | 97 min | Drama, Mystery, Sci-Fi
A young programmer whose job is to watch over the reality-warping Cube defies orders to rescue an innocent mother trapped in one of its rooms.
Director: Ernie Barbarash | Stars: Zachary Bennett, Stephanie Moore, Martin Roach, Michael Riley
Votes: 42,717
25. Human Experiments (1979)
R | 86 min | Crime, Horror, Thriller
A demented prison doctor performs gruesome shock therapy experiments on inmates.
Director: Gregory Goodell | Stars: Linda Haynes, Geoffrey Lewis, Ellen Travolta, Lurene Tuttle
Votes: 883
26. Wyrmwood: Road of the Dead (2014)
Not Rated | 98 min | Action, Comedy, Horror
A talented mechanic prepares to battle his way through hordes of flesh-eating monsters after his sister is kidnapped on the eve of a zombie apocalypse.
Director: Kiah Roache-Turner | Stars: Jay Gallagher, Bianca Bradey, Leon Burchill, Keith Agius
Votes: 18,374
27. Wit (2001 TV Movie)
PG-13 | 99 min | Drama
A renowned professor is forced to reassess her life when she is diagnosed with terminal ovarian cancer.
Director: Mike Nichols | Stars: Emma Thompson, Christopher Lloyd, Eileen Atkins, Audra McDonald
Votes: 11,405
28. Limetown (2019)
TV-14 | 30 min | Crime, Mystery, Sci-Fi
Follows Lia Haddock, a journalist for American Public Radio (APR), as she unravels the mystery behind the disappearance of over 300 people at a neuroscience research facility in Tennessee.
Stars: Jessica Biel, Sherri Saum, Stanley Tucci, Omar Elba
Votes: 3,265
29. The Beast in Heat (1977)
Not Rated | 88 min | Horror, War
A beautiful, nefarious senior female SS officer/doctor creates a genetic, mutant human hybrid; the beast is a, squat, mongoloid hyper-sexually-driven fiend which she uses to torture and molest female prisoners while get fellow Nazis watch.
Director: Luigi Batzella | Stars: Macha Magall, Gino Turini, Edilio Kim, Xiro Papas
Votes: 1,949
30. Wolfenstein: The New Order (2014 Video Game)
M | Action, Adventure, Drama
After regaining consciousness following an injury sustained in World War II, legendary American commando, B.J. Blazkowicz, awakens from a coma in a dystopian Nazi dominated world of 1960s. He tries to locate the remnants of the resistance.
Director: Jens Matthies | Stars: Brian Bloom, Alicja Bachleda, Gideon Emery, A.J. Trauth
Votes: 6,594
31. Call of Duty: Black Ops III (2015 Video Game)
M | Action, Adventure, Horror
The third installment of the Call of Duty: Black Ops franchise brings the player to a dark twisted future with a built-up war storyline.
Director: Jason Blundell | Stars: Omid Abtahi, Orion Acaba, Abdul Alvi, Ike Amadi
Votes: 8,098
32. I.Q. (1994)
PG | 100 min | Comedy, Romance
A mechanic romances the mathematician niece of physicist Albert Einstein, with help from him and his friends.
Director: Fred Schepisi | Stars: Tim Robbins, Meg Ryan, Walter Matthau, Lou Jacobi
Votes: 26,637 | Gross: $26.37M
33. Dr. Alien (1989)
R | 90 min | Comedy, Sci-Fi
A sexy substitute teacher replaces a teacher who was killed by a UFO encounter, but her research on a nerdy student is now making him a lady magnet.
Director: David DeCoteau | Stars: Billy Jayne, Judy Landers, Olivia Barash, Stuart Fratkin
Votes: 1,302
34. The Million Eyes of Sumuru (1967)
Not Rated | 95 min | Action, Adventure
Sumuru, a megalomaniacal femme fatale, makes a bid for world domination by eliminating male leaders and replacing them with her sexy female agents.
Director: Lindsay Shonteff | Stars: Frankie Avalon, George Nader, Shirley Eaton, Wilfrid Hyde-White
Votes: 1,315
35. The Caller (1987)
R | 97 min | Mystery, Sci-Fi, Thriller
A woman, living in an isolated cabin, lets a mysterious stranger in to make a phone call.
Director: Arthur Allan Seidelman | Stars: Malcolm McDowell, Madolyn Smith Osborne
Votes: 1,647
36. Control (2004)
R | 104 min | Action, Crime, Thriller
A sociopath on death row is given a chance to live if he agrees to take part in a chemical behavioral modification program.
Director: Tim Hunter | Stars: Ray Liotta, Willem Dafoe, Michelle Rodriguez, Stephen Rea
Votes: 8,060
37. Shadowzone (1990)
R | 88 min | Horror, Sci-Fi
Scientists experiment with Extreme Dream Sleep and find a Parallel Dimension. Now they find the door works both ways and something has come through.
Director: J.S. Cardone | Stars: Louise Fletcher, David Beecroft, James Hong, Frederick Flynn
Votes: 1,320
38. Maruta 2: Laboratory of the Devil (1992)
96 min | Drama, Horror, Thriller
In the spring of 1935, Japan established a secret base, Unit 731 in Manchuria, where many innocent Chinese, Korean and Mongolian people were killed in grotesque experiments. An idealistic ... See full summary »
Director: Godfrey Ho | Stars: Yishou Jiang, Yuen-Ching Leung, Xingqiang Li, Dingyao Liu
Votes: 665
39. SS Lager 5: L'inferno delle donne (1977)
96 min | Horror, War
During the last days of WW2, several female prisoners arrive at Camp 5 to work as sex slaves for officers and guinea pigs for horrific experiments by Nazi doctors who are trying to find a ... See full summary »
Director: Sergio Garrone | Stars: Paola Corazzi, Rita Manna, Giorgio Cerioni, Serafino Profumo
Votes: 647
40. Rubber's Lover (1996)
Not Rated | 91 min | Horror, Sci-Fi
Scientists use a brain-altering drug to conduct experiments, after one such project goes astray, they need to find another test subject in this Japanese splatter-punk film.
Director: Shozin Fukui | Stars: Nao, Norimizu Ameya, Yôta Kawase, Mika Kunihiro
Votes: 1,089
41. Blood+ (2005–2006)
TV-MA | Animation, Action, Adventure
In present day Okinawa, a young amnesiac girl named Saya combats vicious, shape-shifting vampires. Her adoptive family and friends help her track down their source and uncover her past.
Stars: Eri Kitamura, Katsuyuki Konishi, Hiroyuki Yoshino, Akiko Yajima
Votes: 4,855
42. The Leech Woman (1960)
Not Rated | 77 min | Horror, Romance, Sci-Fi
An endocrinologist in a dysfunctional marriage with an aging, alcoholic wife journeys to Africa seeking a drug that will restore youth.
Director: Edward Dein | Stars: Coleen Gray, Grant Williams, Phillip Terry, Gloria Talbott
Votes: 2,145
43. Brain Twisters (1991)
R | 91 min | Drama, Horror, Sci-Fi
Employees of a software company discover a conspiracy to use the games made by the company to control the thoughts of its customers.
Director: Jerry Sangiuliano | Stars: Farrah Forke, Terry Londeree, Joe Lombardo, Donna Bostany
Votes: 537
44. Testees (2008)
TV-MA | 30 min | Comedy
Two close friends are employed as guinea pigs for a pharmaceutical company. Each episode deals with the different "Research Products" given to the "Test Subjects". There are other stories playing throughout the seasons.
Stars: Jeff Kassel, Steve Markle, Joe Pingue, Kim Schraner
Votes: 2,655
45. The Marijuana Conspiracy (2020)
124 min | Drama
In 1972, young women looking for a fresh start in life endure isolated captivity in a true 98-day human experiment studying the effects of marijuana on females.
Director: Craig Pryce | Stars: Julia Sarah Stone, Hannah Vandenbygaart, Daniel DeSanto, Craig Burnatowski
Votes: 205
46. The Mad Doctor of Market Street (1942)
Passed | 61 min | Comedy, Crime, Drama
A mad scientist is forced to leave San Francisco when his experiments become known. He lands on a tropical island, takes control and terrorizes the local populace. The survivor of a ... See full summary »
Director: Joseph H. Lewis | Stars: Una Merkel, Lionel Atwill, Nat Pendleton, Claire Dodd
Votes: 552
47. Outpost: Rise of the Spetsnaz (2013)
Not Rated | 87 min | Action, Horror, Sci-Fi
In this third installment of the hit Nazi Zombie action horror movie, Outpost: Rise Of The Spetnaz, we discover the horrifying origins of these supernatural soldiers and see them in ... See full summary »
Director: Kieran Parker | Stars: Bryan Larkin, Iván Kamarás, Velibor Topic, Laurentiu Possa
Votes: 2,494
48. The Capture (2017)
78 min | Sci-Fi, Thriller
A group of scientists discover a soul guide and perform an experiment on her even though such ungodly act could cause space and time to bend and alter the very fabric of the universe.
Director: Jim Agnew | Stars: Jonathan Howard, Nora-Jane Noone, Jordan Tisdale, Annie Monroe
Votes: 6,863
49. Frozen Scream (1975)
Not Rated | 85 min | Horror
Mad scientists turn people into frozen zombies and the zombies wreak havoc and kill people.
Director: Frank Roach | Stars: Renee Harmon, Lynne Yeaman, Wolf Muser, Thomas McGowan
Votes: 628
50. Manster (1959)
Not Rated | 73 min | Horror, Sci-Fi
An American journalist stationed in Japan is given a mysterious injection by a mad scientist, turning him into a murderous, two-headed monster.
Directors: George P. Breakston, Kenneth G. Crane | Stars: Peter Dyneley, Jane Hylton, Tetsu Nakamura, Terri Zimmern
Votes: 1,666