Don opens his show discussing the frustrations of doing a weekly show. He welcomes Bob Williams and his amazing dog plus the characters of Disney on Patafe
Tommy Roe performs "We Can Make Music." Leslie Uggams sings " Somewhere. " In a comedic skit Don practices first aid on Dan Blocker. Guest Don Williams shows how his dog catches criminals.
Don welcomes guests the Lennon Sisters who perform 'Long, Long Time"_and "Looking Out My Back Door." Mac Davis sings "In the Ghetto." Don joins Chuck Connors in skits including one about captaining a lifeboat.
The Association performs "Silver Morning" and "Traveler's Guide." Jill St. John sings " Snowbird. " Don conducts the Boston Symphony with help from Robert Morse. Knotts, Morse, and Elaine Joyce are in a comedic skit about blind dates.
The Tapestry sings "Hard to Handle. Irene Ryan joins Don Knotts in a skit about women's lib. Bobby Sherman performs the mega hit "Make Your Own Kind of Music."
Don's guests Roy Rogers and Dale Evans perform a medley featuring Roy's yodeling. Don and Chuck Connors discuss women Don is an expectant father in a wordless skit then is a new tenant.
Don debuts a new comedic character Jesse Fender. Louis Nye is an unintentional comedic U.N. interpreter. Both Mama Cass and Steve Lawrence perform solo numbers then join for a duet.
Don portrays the designer of the "unsinkable" Titanic. In another skit Don tries to sneak someone into a theater managed by Raymond Burr. Jimmy Durante enlists Don, Raymond, and Connie Stevens in performing "Inka Dinka Doo."
Guest Gina is a prisoner who tries to convince attorney Van Johnson she should be free. The Dilliards perform "Tennessee Breakdown" and "Listen to the Sound."
Mary Costa sings "Ah, Je Viex Vivre." The Dilliards perform " One A.M. " Newhart does a monologue about a man returning Christmas presents in April. Don duets with Mary on "Why Do I Believe?"
Don welcomes Tony Randall who plays a priest and a man taking his pet ant to a veterinarian. He also challenges Knotts to a pool game. Claudine Longet helps Don with his French and sings a medley of songs.
Michael Landon portrays a hero returning to his hometown Charles Nelson Reilly plays a NBC tour guide with a lack of attractions. Loring and Davidson sing solos then join for a duet.