In the original script, Rosalie, the woman in the wheelchair at Peggy Sue's high school reunion, was a gymnast who was crippled in an accident. In the original script, Peggy Sue tried to take advantage of her knowledge of the future. She invented pantyhose, encouraged people to invest in Xerox, and tried to prevent Rosalie from hurting herself.
While "visiting" 1960, Peggy Sue warns her sister about eating red M&Ms. Red M&Ms were discontinued in 1976, when Red #2 dye was named as a suspected carcinogen. In 1986--after the film was released--red M&Ms were reintroduced with a different red dye.
The blue 1958 Chevrolet Impala convertible that Nicolas Cage drives was later given away in a sweepstakes tied in with the opening of the film.
Sofia Coppola (director Francis Ford Coppola's daughter) plays Peggy Sue's little sister. Sofia would later direct Kathleen Turner in The Virgin Suicides (1999).