Unhappy with Vincent D'Onofrio's verbal impersonation of Orson Welles, Tim Burton had his voice dubbed by Maurice LaMarche.
One day, Kathy Wood, Edward D. Wood Jr.'s wife, visited the set and asked to meet Johnny Depp. That day, they were filming a scene where Wood would look really messed up, which made Burton nervous for what Kathy would think of the movie. When Depp exited his trailer, she said, "That's my Eddie."
At the time, Johnny Depp was depressed about films and filmmaking. By accepting this part, it gave him a "chance to stretch out and have some fun", and working with Martin Landau "rejuvenated my love for acting".
Tim Burton said that he was drawn to the story because of the similarities between Edward D. Wood Jr.'s relationship with Bela Lugosi and his own friendship with Vincent Price late in the actor's life.
Gregory Walcott: the potential backer who introduces Wood to Vampira. Walcott played Jeff Trent, one of the lead roles in Plan 9 from Outer Space (1957). In real life, Wolcott was the one put forward by the Baptist investors to play the lead in Plan 9, which resulted in Woodl's depicted meltdown in the film. He was a member of the congregation and was a busy actor in TV and occasional screen roles.
Scott Alexander, Larry Karaszewski: the film's screenwriters are the white-tuxedo-clad members of Vampira's entourage at the Brown Derby.