Dr. Roger Cattan, Dr. Tim Lonner, and Dr. Evan Newman are starting a new L.A. medical practice. They are tired of the old system and try to treat their patients more humanely. That's why Dr. Sarah Church wants to join.
Dr. Cattan struggles with Kevin who reveals that he's underage complicating his treatment. Dr. Lonner struggles with Gus who refuses help and driven to run. Dr. Newman struggles with alien-obsessed Charlie. Julie is frustrated with Tim.
Dr. Lonner treats young dying patient Zach. The parents are desperate to get into an experimental trial and Dr. Cattan has a contact. Dr. Newman's ex-wife Kelly wants to move the family out of L.A. Suzanne suspects that Felicity has OCD.