Nancy Travis was originally hired to play Chris for just four episodes, and at the end of Season 4 was to disappear after John Becker (Ted Danson) chose to be with Reggie Kostas (Terry Farrell). But the producers decided to fire Farrell and keep Travis on as a full time character.
There have been numerous references to Danson's former series "Cheers" (1982). Cheers co-stars George Wendt, Rhea Perlman and Kelsey Grammer have all appeared on the show: Wendt playing the barman to Danson's character (On "Cheers", Danson played the barman to Wendt's character) and Grammer playing an alcoholic friend of Danson's Harvard-graduate doctor (on "Cheers" and "Frasier" (1993), Danson played an ex-alcoholic and Grammer played the Harvard-graduate doctor. Rhea Perlman appeared as a therapist with an optimistic view on life, with Danson as the character who's not happy with his life (on "Cheers", Danson plays the cheery character and Perlman's the one who's not happy with her life).
In one episode, Bob is walking out of Reggie's Diner as Becker walks in. He says, "Out of my way Gulliver," referring to Ted Danson's role in Gulliver's Travels (1996) (TV)
Dr. John Becker's office phone number is 555-0199.
Bob disappeared at the start of the 6th season, the character was said to "be on vacation" and was then never referred to again. This was because Saverio Guerra had left the show between the 5th and 6th seasons.
In the first few episodes of the first season, Linda (Shawnee Smith is seen wearing a lab coat, even though neither Dr. Becker nor Nurse Maragret wear one. This is because Smith was pregnant at the time and the lab coat was to hide her pregnancy.
The character of Margaret's husband, Lewis, is never seen in the show, a gag in the tradition of "Cheers" (1982), in which Norm's wife, Vera, is never seen, and "Frasier" (1993), in which Niles' wife, Maris, is never seen.