Winona Ryder broke her arm while shooting the scene in which she and Adam Sandler ride bikes down the stairs.
When Babe, pretending to be a school nurse, talks to Longfellow on the phone, she says that a boy named Billy Barty is in her office, sick. This is a tribute to actor Billy Barty, who died in 2000, three months before production started.
When Babe and Deeds are talking in a restaurant after a fake criminal act set by her, Deeds talks about how Stephen King visited his town, and how one guy lost two hundred pounds after making eye contact with him, a reference to Thinner (1996).
Repeat character: Rob Schneider as the delivery driver, the same character he played in Big Daddy (which came out 3 years earlier)