The character's name "Michael Griffin" is a direct reference to the character of "Griffin" from H.G. Wells' 1897 serial novel "The Invisible Man". In Wells' story, Griffin was driven insane by his invisibility - much like the character in this movie.
The prescription bottle Frank Turner places on Detective Harrison's desk is labeled "Kindasortacyn" and its generic equivalent, "Somethinesleacyn".
There were only 250 visual effects shots in the whole film, and 80 of them were simply wire removals.
The flashback scene in which Christian Slater is becoming invisible re-uses footage from the original Hollow Man (2000).
Paul Verhoeven: The newspaper photo of one of the killed doctors is of the director of the first Hollow Man (2000). The photo was taken on location while filming Starship Troopers (1997), but has been altered for its use in this film.