This was Burgess Meredith's final appearance as the Penguin on the series. The character did make a brief cameo in the series' penultimate episode, but an unknown actor played the role, while Meredith appeared uncredited as The Penguin (but not in his actual costume and without his fake nose) in a silent cameo, except a light sqawking laugh, in Monkees Blow Their Minds (1968), which was the penultimate episode of that series.
John Beradino plays a parody of the doctor character that he played on General Hospital. He starred as the unflappable Dr.Steven Hardy. Beradino also had an earlier successful career as a professional baseball player.
Sleeping sickness is a real malady in tropical Africa, and is spread by the tsetse fly. Lygeria is likely a pun on the African nation of Nigeria.
Penguin's henchmen wear the names Dustbag and Push Broom, two terms used in cleaning up by vacuum or sweeping---a tie in to the show title
Alfred breaks the fourth wall in a delightfully British way. Bravo!