Inferno calls Rampage a drone in this episode. A drone is a male ant whose main purpose is to mate with the queen ant to provide offspring. Given Inferno's beast mode (a fire ant) and the fact that he refers to Megatron as "the royalty," this would probably be a perverse insult.
Optimus Primal speaks about stopping Megatron "at any cost." This is a reference to Optimus Primes original quote from The Transformers: The Movie (1986): "Megatron must be stopped... no matter the cost."
Waspinator refers to himself in first person. Also worth noting is that he calls Megatron "Dragon-Bot", even though up to this point, he always used his real name.
We learn that Waspinator's robot-mode has an incredibly huge, fleshy, yellow colored tongue. In an earlier episode, we saw his beast-mode tongue too, which was red in color.
"Nemesis" is the series' finale. It was planned to be a three episodes long, but was compressed to a two-parter.