The only time on screen or television that Boris Karloff was asked to portray a female character.
The casting of Boris Karloff as Mother Muffin later served as the inspiration to cast Edward Asner as Granny Goodness, a minion of Darkseid, in Superman: The Animated Series (1996).
Only screen appearance of William Tuttle, well known makeup artist, as Henchman Tuttle, Mother Muffins makeup artist.