This is the first episode to not feature Chandra Wilson (Bailey).
When Meredith uses her stethoscope to listen to the old lady's lungs after intubating her, she uses the stethoscope backwards.
The method Dr. Christina Yang uses to mark the infection in order to see if the infection is spreading, is the correct method used in hospitals.
When Meredith puts the tube in the old woman named Grace, her three friends talk to Meredith about her DNR saying "Her daughter Alice was there with her girlfriend: she's a lesbian" and goes on and on. Also in this episode Leisha Hailey plays the character Claire Solomon with the flesh eating virus in her leg. But Leisha also stars in the show The L Word where she plays a lesbian named Alice.