When Izzie Stevens had to rip off her clothes in the locker room, Katherine Heigl said, "If I have to take off all my clothes, then some of the crew should have to take off their clothes." The episode's director, the director of photography, and the show's producer all stripped down to their skivvies.
Dr. Shepard and Meredith Grey have a patient with a tumor in his hypothalamus and they state he will lose his memory if they remove the tumor. However, the hypothalamus is not responsibile for memory; that is primarily the hippocampus.
Every episode is named after a famous song. This episode may refer to either Alice Cooper's or Billy Joel's "No Man's Land".