Helen Banner was created specifically for the show. Bruce's family life had not yet been explored in the comic. The producers at one point thought of bringing her back and having her become a female Hulk, but the show was canceled before this ever came to pass. Marvel Comics, however, knew that the producers were considering this, and created She-Hulk as a result.
Fred Rogers famously visited the set of this episode to show his young viewers how the series was made.
"Homecoming" is about the only episode to reveal any detail regarding David Banner's background.
Diana Muldaur had previously appeared with Bill Bixby in the episode "And Eddie Makes Three" on the show The Courtship of Eddie's Father (1969-1972).