George Segal (Jack Gallo) and Jessica Walter (Eve Gallo) died only one day apart: Segal on March 23, 2021 and Walter on March 24, 2021.
Dan Butler guest stars. At the time of broadcast, Butler was also playing recurring character Bulldog Briscoe on fellow NBC series Frasier. "Eve of Destruction" first aired right after the new Frasier episode, "Roz and the Schnoz", although Butler did not appear in that episode.
Eve makes a derogatory reference about Dennis Finch to Maya. Jessica Walter (Eve) and David Spade (Finch) previously worked together in PCU (1994). She played the evil University President and he played a snotty WASP student who was conspiring with her while continually trying to hit on her.