Paul Adelstein appears uncredited as a character named "Kellerman." Starting in 2005, he would begin playing the regular character of Agent Kellerman on Prison Break (2005).
Viola Davis plays a defense attorney is this episode. She would later go on to play successful lawyer Annalise Keating in the hit show How to Get Away with Murder (2014).
In 2022, two babies received the first-ever gene therapy for Tay-Sachs disease, after over 14 years of development. As of 2024, unfortunately there is still no cure for Tay-Sachs. Aggressive medical treatment can extend survival, but does not improve neurological function. The increasing cost of manufacturing these treatments makes it extremely difficult, if not impossible, to develop and test gene therapy for many ultra-rare diseases, where the number of patients worldwide is very small and profitability low.
Since the 1970s, the number of babies born with Tay-Sachs has reduced significantly due to genetic screening.