The title is based on the platitude "Some of by best friends are..."
According to this episode, Mary spent two years at the University of Minnesota, where she pledged Gamma Gamma Delta.
Two episodes before this one, Rhoda lost everything in her apartment to a fire. In this episode her apartment looks exactly the same as in previous shows.
In this episode, Mary Frann plays a woman named Joanne. Years later she co-stars in the show Newhart (1982) which is also a MTM Production, where she plays a character named Joanna.