- Ms. Glass gives a lecture on STDs and prepares a Cabaret-type musical on the subject. The students are to play the STDs. Sam wants to lose her virginity with George but he's not ready. Sugar and Josh hire a cool prostitute for Harrison.
- "Fire in the Hole" Harrison returns to school, Sugar and Harrison planning him a welcome back surprise. Ms. Glass tells her students that they must perform in a play she has written about sexually transmitted diseases. While Sam tries to have her first time with George.—Ron Storey
- Harrison is back in school after his recovery from leukemia. The topic of Ms. Glass' latest class are STDs. After the lecture, she announces her plans to produce her school play "That Burning Sensation: A Cautionary Tale", a pro-abstinence "Cabaret"-type musical about the subject. She picks Sam's boyfriend George to play chlamydia, Lily as gonorrhea, weirdly exited April Tuna as syphilis, Josh and Sugar as genital warts, Nicole and Mary Cherry as crabs, Brooke as herpes, Sam as "the whore" and Harrison as the virginal boy, who must resist temptation. Carmen also gets a less than stellar part. Meanwhile, Sam tries to lose her virginity with George but he's not ready yet. She takes Brooke's advice to try to be more aggressive and seductive with him but that completely backfires. She later learns that he's not exactly a "virgin" virgin and tries to uncover the real reason why he's not ready to have sex with her at this time. Josh and Sugar have already lost virginity, so they joke about it in a friendly fashion with Harrison, who starts feeling peer-pressured and decides to finally have sex as well. The guys offer to buy him a prostitute. Insulted, he refuses. However, it turns out that finding a girl to sleep with him is not as easy as he originally thought, especially after he propositions already willing Nicole in a very clumsily worded and insultingly blunt way. He eventually gives in and accepts Josh and Sugar's offer. Lily learns about this and as a feminist gets very angry at Josh. Sam is also not into the idea. Harrison visits the woman, Candy Box, who turns out to be a very nice and cool lady, who loves to bake fantastic pies. Before he gets the chance to decide whether he wants to do it with her or not, Sam barges in trying to uncover more information about George's past. The episode ends with the play and a pro-abstinence message.
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