This and all episodes from 2001 do not feature the traditional opening sequence, or even the title of the show.
This episode was originally made to feature the Aqua Teens, but when Mike Lazzo read the script he had the writers rewrite it so Willie Nelson would have a more prominent focus in the episode. Therefore a whole new plot where a shark is in front of the desk because of a Liquor corporation merger with a talking worm in charge, a bear attacking Space Ghost and a documentary regarding the shark and bear was created with Willie Nelson talking to Space Ghost and company regarding the shark and bear.