The title is based on the name that Tonto called the Lone Ranger, Kemosabe.
When Dr. Novino remarks that Pee-Wee (Matt Frewer) didn't "catch the wave," it's a reference to Frewer's appearance as Max Headroom in Coca-Cola ads of the the time. "C-C-Catch the Wave - Coke!" was the campaign's slogan. (This was also Frewer's first TV appearance after the cancellation of the Max Headroom TV series.)