This episode is based on the experiences Jessie's Japanese voice actress Megumi Hayashibara had during nursing school.
Jessie is revealed to have studied at Pokémon Nurse School.
This episode marks the second time a character is shown bleeding (in this case, Ash). The first time was in Wake up! Kabigon! (1998), where Misty was seen bleeding.
This episode's English title is a reference to the popular saying "ignorance is bliss".