Kirsten Dunst couldn't supply her voice of Mary Jane Watson for the game franchise due to her hectic schedule and was replaced by Kari Wahlgren. Yet Dunst's name is still in the opening credits. This s also the third time a different actress is playing Mary Jane Watson in a game based on the Sam Raimi Spider-Man movies with the character being voiced by Catherine O'Connor in Spider-Man (2002) and Dunst in Spider-Man 2 (2004).
The collector's edition of the game (only available for the PS3 version) allows you to play as the New Goblin after completing the game. Later this was made available for download on the Playstation Store for anyone who had the regular PS3 edition.
In the Wii and PS2 version, there is a recurring optional mission in which members of a gang steal fruit pies. This is a reference to the Spider-Man comics from the 70's, which contained ads for Hostess fruit pies.
This is the first time James Franco voiced Harry Osborn/New Goblin, unlike the previous games, Spider-Man (2002) and Spider-Man 2 (2004), where Harry Osborn was voiced by Josh Keaton.
The game was released on May 4th 2007, the same day as the Spider-Man 3 (2007) movie opened in theaters.