- Dorothy Ann: I'm hot.
- Tim Jamal: I'm tired.
- Ralphie Tennelli: I'm hungry.
- Arnold Perlstein: [importantly] I'm prepared.
- Phoebe Terese: [as the bus, now a plane, flies over mountains] Ms. Frizzle, we must be going the wrong way.
- Ms. Valerie Frizzle: Wrong way? Why, Pheobe, if it weren't for these mountains, there wouldn't even be a desert.
- Arnold Perlstein: [reading his field trip survival guide] Field trip tip number 63: In the event of a rapid loss of altitude, you may want to put on a parachute.
- Arnold Perlstein: Field trip tip number 158: When the sun is beating down on your head, put on a hat. Got that covered!
- Ms. Valerie Frizzle: As I always say: make mistakes, make mistakes, make mistakes! It's the best way to learn something.
- Arnold Perlstein: Field trip tip number 107: To avoid being eaten, become inedible. What does that mean?
- Arnold Perlstein: Field trip tip number 257: To beat the heat, do like most desert animals: come out only at night.
- Arnold Perlstein: Field trip tip number 999: For those without desert adaptations, always travel with a teacher with frizzy red hair.
- Ms. Valerie Frizzle: Yes, all things that live here have adaptations for survival. Ah, it makes so much sense, doesn't it?
- Phoebe Terese: I might have made a mistake about that lizard. And I might have made a mistake about that jackrabbit. And I might have even made a mistake about that tortoise, but there's one thing I know I'm not wrong about.
- Arnold: How much you wish you'd stayed home today?