Lindsay Monroe (Anna Belknap) was bitten by a cobra at the beginning of the episode. The writers used this incident to hide the fact Belknap was pregnant.
Erik Smith (Jesse Quinn) also appears in A Night at the Movies (2003) (#3.19) as "Timmy McCallum" and in Show Stopper (2010) (#8.12) as "Robbie Ferguson".
John Wesley Shipp (Patrick Quinn) played forensic scientist/superhero Barry Allen (aka "The Flash") on the short-lived television series The Flash (1990). Interestingly, fellow guest star Kyle Gallner (Reed Garrett) played a younger Flash ("Bart Allen") on CW's Smallville (2001).
Stacy Haiduk (Debra Archerson) also appears in Bittersweet (2011) as "Gina Sinclair" and in Body Count (2003) as "Dawn Kaye".
The Spanish title of the episode is "Felices 16", meaning "Happy 16".