The show was originally called "Sex Life". It was still called Sex Life after the pilot. At some point between filming and the actual airing on HBO, the show's named was changed to "Tell Me You Love Me."
Michelle Borth (Jaime) and Luke Kirby (Hugo) end up both working with actor Zachary Levi in separate projects. Michelle worked with Zachary in Shazam! (2019), playing Super Hero Mary and Shazam respectively and Luke worked with Zachary in The Marvelous Mrs. Maisel (2017), playing Lenny Bruce and Benjamin Ettenberg respectively.