The episode was recorded on May 23, 1990.
The title of this episode is a reference to the saying "Very Best Friends."
Kishar and Anshar are both part of actual mythology. Kishar is in Babylonian mythology while Anshar is from both Babylonian and Sumerian. Both are associated with the same elements in the episode.
The Ghostbusters arrive at Sheepshead Bay Marina. It is an actual location in Brooklyn.
Ray owned a sailboat he named the "SS Pollywog". The name "Pollywog" is a common name for small boats. The term is also the name of sailors that have not crossed the Equator, which they call "Slimy Pollywogs".