As a hardcore gamer geek, this show really speaks to me. I've been gaming for twenty-some years and counting, and this wonderful show is riddled with game-related jokes from start to finish. I don't expect non-gamers to appreciate it too well, but anybody that's spend a decade or two with a game controller in hand should find the show entertaining enough.
It has the silly absurdity of South Park, not to mention the vulgarity, but the cast of characters are adults working at a fictitious game development studio. The art direction is interesting because it's obviously intended to appear like a classic 8-bit video game, on a system like the NES, complete with overly-pixilated character sprites. Each episode is intended to appear as if playing some sort of weird video game, with each show beginning with a start screen and ending with a "game over" screen, and typical in-game stuff like a score or health meter appears at the top of the screen, though sometimes swapped out with other gaming oddities like items collected. The show pauses for commercial breaks.
I wouldn't recommend this show to non-gamers, but to the hundreds of millions of gamers out there, this show comes highly recommended.