On the series premiere, eight drug addicted celebrities check themselves into rehab under the care of Dr. Drew Pinsky and begin their difficult battle for sobriety.
As the treatment process begins, all of the patients are experiencing intense physical withdrawal symptoms, but none more than Ashleigh. Later, the three remaining patients arrive.
Jeff finally returns from the hospital, but while he continues to detox, Drew lectures Jeff's co-dependant girlfriend about her own bad habits will kill Jeff.
Dr. Drew let's Celebs in Rehab have a fun BBQ and see their friends and guests. Mary Carey invites her friend Rena Riffel (Showgirls/Striptease) and they talk with Jeff Conaway. Rena leaves early, and a wet t-shirt contest goes bad.
After weeks of detox, withdrawal, therapy and healing, it is graduation time. With the news that sober living will be provided free of charge, the cast struggles with the decision to continue treatment after rehab, or to go home and face temptation.