Composer Yôko Kanno, who scored the music for Cowboy Bebop (1998), returns to score the music for this series.
Kôichi Yamadera was enthusiastic about reprising his role as Spike Siegel: "Cowboy Bebop is an important work for me. I have long anticipated a live-action version. I can feel the strong respect it has toward the anime. I hope that viewers will see the atmosphere of the Spike character that I previously portrayed in John Cho's performance, who is skillfully taking on the role in this version. There are also many settings and developments that can only be pulled off in a live-action series. I hope that both people who love Cowboy Bebop and those who are new to the title can enjoy this new series!".
The Japanese dub of the show has the original voice actors of Cowboy Bebop (1998) reprising their original roles: notable examples includes Kôichi Yamadera (Spike Spiegel), Megumi Hayashibara (Faye Valentine), Norio Wakamoto (Vicious) and Gara Takashima (Julia). The exception is Jet Black, who is played by Taiten Kusunoki; Kusunoki replaces Black's original voice actor Unshô Ishizuka, who had passed away in 2018. Other replacements are Masako Isobe, who replaces Kazuaki Ito as Spike's former mentor Mao, and Romi Park, who replaces Nobuyuki Hiyama as one of Vicious' twin enforcers Shin.
In 2008, it was reported that 20th Century Fox had a script, penned by Peter Craig, in circulation for the live-action adaptation of the hit anime series Cowboy Bebop, and were planning on developing the script into a movie. Anime creator Shinichiro Watanabe claimed to be on board with the idea and was appointed as executive producer, along with some of the original anime's writers. Although they still didn't have a director on their team, they were enthusiastic about the concept and planned to release the movie in 2011, with Keanu Reeves cast as Spike. Unfortunately, the movie missed its 2011 release date, and in 2013, Reeves commented on Reddit saying,"Cowboy Bebop does not look like it's going to happen with me in it. ...It would cost, like, half a billion dollars to make it...".
Mason Alexander Park (Gren) has a tattoo with the phrase, "Whatever happens, happens." It is one of the most popular quotes in Cowboy Bebop (1998).