One of the few Family Guy episodes to receive a TV-MA rating due to coarse language including some uses of "fuck" regardless of whether it is said uncensored.
Seth Rogen voiced himself for the gag about him.
The musical number near the end of the episode is taken directly from the end musical number in "Blazing Saddles" (1974)
The show has strongly hinted that Glenn Quagmire is either HIV+ or has AIDS but won't take precautions of any kind. When the friend group (Peter, Glenn, Joe and Cleveland) are playing Truth or Dare at one point, Peter asks for a "Truth" from Glenn and when he asks "Do you have AIDS?", Quagmire laughs dismissively and says he's not going to answer the question.