Episode Title: Sweet Surrender
Sweet Surrender is the title of numerous songs performed by artists including Bread, Wet Wet Wet, John Denver, Diana Ross, Rod Stewart and Sarah McLachlan.
While Derek is scrubbing in, Meredith and him are talking about who his best man will be. Meredith mentions that Derek and Mark have been friends for 20 years. We learn earlier in the series that they have known each other since early childhood, and being an attending would put Derek and Mark to be about 40 years old. Which would make their friendship to have lasted over 35 years.
Izzy is obsessed with planning Meredith and Derek's wedding. Katherine Heigl also starred in 27 Dresses which she was obsessed with weddings and wedding planning.