This 2022 All-Star Game will mark the fourth time in franchise history that the Dodgers will hold the Midsummer Classic, including the third time in Los Angeles and the second at Dodger Stadium, which last staged the event in 1980. Previously, the Los Angeles Memorial Coliseum was the site of the second All-Star Game of the 1959 season and in the franchise's Brooklyn lineage, Ebbets Field hosted the 1949 MLB All-Star Game (1949).
The Los Angeles Dodgers were awarded the 2022 MLB All-Star Game after the planned 2020 MLB All-Star Game was canceled due to the COVID-19 pandemic in the United States. This will be the fourth time the Dodgers host an All-Star Game.