The main character's name (Hank J. Wimbleton) wasn't actually revealed until the fourth installment Apotheosis. Before that he was known only as 'The Protagonist'.
When being asked if Sanford was a superhuman like hank and Deimos, Matt "Krinkles" jolly simply replied with "he can eat twice as many spicy wings as hank and Deimos combined."
The series became so popular amongst online communities that in 2007, September 22nd was officially announced as Madness Day. On this day every year, popular and new animators publish tributes and spin-offs of the Madness series and compete to win prizes.
A grunt (a plain gray character) appears in every episode.
Sanford, Hank and Deimo's professional partner is the only character to appear to have lips.