Major inspirations for this show include Night Flight, Liquid Television, and the Manhattan Neighborhood Network series Concrete TV.
The series was originally supposed to contain clips of Adult Swim shows in addition to online material. This idea was scrapped as the network would still have to acquire licenses for their own series for derivative works.
Since September 5, 2014, adultswim.com has been broadcasting an Off the Air channel featuring every episode in a continuous loop. On December 22, 2014, the channel started playing additional short films between episodes.
In many episodes, Space ghost along with Zorak and Moltar are hidden in the scenery of some clips.
The title of the series "Off The Air" is the opposite of the title of the ABC series "On The Air".