The concept for The Blood Widow came from director Jeremiah Buckhalt's personal sketches and was not originally designed for the film.
The project was directed by Jeremiah Buckhalt only a month after graduating from the Film program at Full Sail University, and incorporated the help of fellow classmates, students, and faculty during its production. In total, 19 crew members were drawn from Full Sail, including Game Design instructors Chad Coup and Ian H. Davis, who co-wrote the script.