Shortly thereafter, Simmons responds with "To be or not to be, bitch." That quote, from Hamlet, begins one of Shakespeare's greatest soliloquies, about the decision Hamlet must make: to live and face the trouble he knows is coming, or to commit suicide and face the unknown, which may be even worse.
Endgame is a term used in chess, which refers to the final stage of a game, at which point most of the pieces are removed from the board. In the endgame, strategy changes, as the pawns (the weakest and smallest pieces on the chess board) who protected the king from checkmate, become less important as the king exercises his increasing power. Metaphorically, it is often used for the late revelation of a previously hidden major objective.