In Misty's room, there's a Patient Care Board that says L. Carter and Dr. E. Wirtham, references to Linda Carter and Dr. Elias Wirtham. In the comics, Linda is one of the Night Nurses and Wirtham is the Spider-Man villain Cardiac. Also on the board are Doctors Tony Isabella and Arvell Jones, which are the names of Misty Knight's creators.
Jessica sarcastically calls Danny Ironclad instead of Iron Fist. Ironclad is a Marvel villain and a member of The U-Foes.
Spider-Man is mentioned in the Wu-Tang Clan song "Protect Ya Neck", which is featured in this episode.